Sematilide HCl ( —— )

产品货号. M17117 CAS No. 101526-62-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Sematilide HCl
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Sematilide (CK-1752) 是一种 III 类抗心律失常药。它是一种选择性延迟整流器 K+ 电流 (IKr) 通道阻断器。
产品描述

Sematilide (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of refractoriness and action potential duration.
体外实验

Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM).
体内实验

Sematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia. Animal Model:Mongrel dogs of either sex (10-18 kg body weight) Dosage:0.3, 1, 3, and 10 mg/kg Administration:I.v. infusions Result:Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.
同义词

——
通路

Others
靶点

Other Targets
受体

K+ current (IKr) channel
研究领域

——
适应症

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1. Yoshida H,et al. Circ J. 2002 Aug;66(8):758-62.

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