Sematilide HCl

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sematilide (CK-1752) 是一种 III 类抗心律失常药。它是一种选择性延迟整流器 K+ 电流 (IKr) 通道阻断器。

Sematilide (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of refractoriness and action potential duration.

Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM).

Sematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia. Animal Model:Mongrel dogs of either sex (10-18 kg body weight) Dosage:0.3, 1, 3, and 10 mg/kg Administration:I.v. infusions Result:Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.

——

Others

Other Targets

K+ current (IKr) channel

——

——

101526-62-9

349.87

C14H24ClN3O3S

>98% (HPLC)

In Vitro:?H2O : 5 mg/mL (14.29 mM)

CCN(CC)CCNC(=O)c1ccc(cc1)NS(=O)(=O)C.Cl

——

(-20℃)

With Ice Pack

≥ 2 years